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Early duplications of opioid receptor and Peptide genes in vertebrate evolution
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Larhammar)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Larhammar)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Larhammar)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Larhammar)
2009 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1163, 451-453 p.Article in journal (Refereed) Published
Abstract [en]

The opioid receptor family in mammals has four members called delta, kappa, mu, and NOP (the nociceptin/orphanin receptor). We show here that they arose from a common ancestral gene through quadruplication of a large chromosomal region, presumably in the two basal vertebrate tetraploidizations. The four opioid peptide precursor genes have a more complicated evolutionary history involving chromosomal rearrangements but nevertheless seem to have arisen in the same time period as the receptors. Thus the system of opioid peptides and receptors was already established approximately 450 Ma at the dawn of gnathostome evolution.

Place, publisher, year, edition, pages
2009. Vol. 1163, 451-453 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-123965DOI: 10.1111/j.1749-6632.2008.03672.xISI: 000266493400061PubMedID: 19456384OAI: oai:DiVA.org:uu-123965DiVA: diva2:317705
Available from: 2010-05-04 Created: 2010-04-30 Last updated: 2017-12-12Bibliographically approved

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