Palladium(II)-catalyzed coupling reactions with a chelating vinyl ether and arylboronic acids: a new Heck/Suzuki domino diarylation reaction
2009 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 48, 7587-7589 p.Article in journal (Refereed) Published
A mild and novel palladium(II)-catalyzed domino Heck/Suzuki alpha,beta-diarylation-reduction of a dimethylaminoethyl substituted chelating vinyl ether was developed by using electron-rich arylboronic acids in combination with p-benzoquinone. Based on the preparative results, a catalytic cycle is proposed. Further, highly regioselective palladium(II)-catalyzed alpha- or beta-monoarylation of the chelating vinyl ether was achieved using either a bidentate ligand or by employing ligand-less conditions.
Place, publisher, year, edition, pages
2009. Vol. 48, 7587-7589 p.
Research subject Organic Pharmaceutical Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-124718DOI: 10.1039/b918358bISI: 000272238900039PubMedID: 20024288OAI: oai:DiVA.org:uu-124718DiVA: diva2:317917