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Personality and the serotonin transporter gene: Associations in a longitudinal population-based study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
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2009 (English)In: Biological Psychology, ISSN 0301-0511, E-ISSN 1873-6246, Vol. 81, no 1, 9-13 p.Article in journal (Refereed) Published
Abstract [en]

Associations between the promoter polymorphism of the serotonin transporter gene (5-HTTLPR) and anxiety-related personality traits in healthy adult subjects have been inconsistent. We assessed personality in participants of the Estonian Children Personality Behaviour and Health Study, using parental reports and self-reports. In the younger cohort, according to parental assessments at ages 9 and 15, children homozygous for the S allele had significantly higher scores of Neuroticism and lower scores of Openness, Agreeableness and Conscientiousness. Parental assessment of the older cohort at ages 15 and 18 did not yield any genotype effect on personality; however, interaction of cohort and genotype was not significant. According to self-reports, SS homozygotes had higher Neuroticism at age 15 but not at age 18. Thus, homozygocity for the S allele of the 5-HTTLPR is related to anxiety-related personality traits in general population, but this is easier to detect before adolescence.

Place, publisher, year, edition, pages
2009. Vol. 81, no 1, 9-13 p.
Keyword [en]
Serotonin transporter, Promoter polymorphism, Children, Adolescents, Personality, Development
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:uu:diva-124727DOI: 10.1016/j.biopsycho.2009.01.001ISI: 000265327300002PubMedID: 19437595OAI: oai:DiVA.org:uu-124727DiVA: diva2:317919
Available from: 2010-05-05 Created: 2010-05-05 Last updated: 2012-02-06Bibliographically approved

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