uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Taking the patient's side: the ethics of pharmacogenetics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
2010 (English)In: Personalized Medicine, ISSN 1741-0541, Vol. 7, no 1, 75-85 p.Article in journal (Refereed) Published
Abstract [en]

From the perspective of current and future patients, the development of the field of pharmacogenetics is of immense interest. The encouraging vision that is now being established is that we may move from trial and error therapies to evidence-based personalized medicine in clinical practice. However, research and the application of pharmacogenetics to clinical practice are believed to raise a host of controversial ethical issues. Some of these are related to the research process, for example, confidentiality and informed consent in association with human tissue sampling. Other issues arise on a societal level, for example, issues regarding justice and the use of race or ethnicity as proxies for genotyping. in this perspective, I comment on this debate and also suggest what we may learn from previous discussions regarding DNA testing and gene transfer methods. Arguably, the most important ethical perspective in medical research and drug development is related to the interests of patients wanting medical treatment that is both effective and carries low risks of adverse effects. Risk:benefit ratios must always be compared with existing alternatives, and while the risk of adverse effects may be tolerable for some individuals, owing to genetic reasons, this may not be relevant for others. This will have consequences for regulatory policies regarding drug development. In the future, personalized medicine will also need to take epigenetic and environmental factors into consideration.

Place, publisher, year, edition, pages
2010. Vol. 7, no 1, 75-85 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-124750DOI: 10.2217/pme.09.47ISI: 000273582900012OAI: oai:DiVA.org:uu-124750DiVA: diva2:317931
Available from: 2010-05-05 Created: 2010-05-05 Last updated: 2011-01-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Hansson, Mats G.
By organisation
Centre for Research Ethics and Bioethics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 190 hits
ReferencesLink to record
Permanent link

Direct link