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Venous saturation slab causes overestimation of stenosis length in two-dimensional time-of-flight magnetic resonance angiography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
2009 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 50, no 1, 55-60 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The use of downstream saturation slabs in two-dimensional time-of-flight magnetic resonance angiography (2D TOF MRA) of the arterial system eliminates signal from regions with countercurrent flow, as seen in veins, but possibly also beyond arterial stenoses because of flow turbulence. PURPOSE: To investigate the contribution of a downstream saturation slab to signal intensity (SI) loss beyond stenoses at 2D TOF MRA. MATERIAL AND METHODS: 2D TOF MRA was performed on a bifurcation phantom with a tight stenosis at 1.5T during pulsatile flow. Qualitative and quantitative evaluations of stenosis delineation were performed with different echo times (TE) (3.7 or 7.0 ms), spatial resolution (1 x 1 x 1 or 1 x 1 x 5 mm(3)), and with or without a downstream saturation slab. For reference, a high-resolution contrast-enhanced sequence without flow was obtained. RESULTS: The downstream saturation slab caused severe signal loss immediately distal to the stenosis, causing overestimation of stenosis length. This region corresponded with a region of poststenotic flow jet, where turbulence is expected. With increase in TE, there was some increased SI loss at the level of maximum stenosis. A lower spatial resolution resulted in overall poorer delineation of the stenosis. CONCLUSION: Using clinically relevant sequence parameters, the use of a downstream saturation slab at 2D TOF MRA was found to be a major contributor to signal loss in stenotic regions, which can result in an overestimation of stenosis length.

Place, publisher, year, edition, pages
2009. Vol. 50, no 1, 55-60 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-124838DOI: 10.1080/02841850802562063ISI: 000262638600008PubMedID: 19052937OAI: oai:DiVA.org:uu-124838DiVA: diva2:318049
Available from: 2010-05-06 Created: 2010-05-06 Last updated: 2012-03-07Bibliographically approved

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Wikström, JohanBjornerud, AtleJohansson, Lars

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