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A versatile new synthetic route to 1N-hydroxyindazoles
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2009 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 11, no 21, 5078-5081 p.Article in journal (Refereed) Published
Abstract [en]

A new and versatile cyclization reaction affording rare 1N-hydroxyindazoles is presented. Treatment of 2-nitrobenzylamines with methanolic sodium hydroxide furnishes 1N-hydroxyindazoles regioselectively and in high yield. The reaction tolerates a range of functional groups and electronic effects.

Place, publisher, year, edition, pages
2009. Vol. 11, no 21, 5078-5081 p.
National Category
Pharmaceutical Sciences
Research subject
Organic Pharmaceutical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-124864DOI: 10.1021/ol902085kISI: 000271097100079PubMedID: 19813736OAI: oai:DiVA.org:uu-124864DiVA: diva2:318069
Available from: 2010-05-06 Created: 2010-05-06 Last updated: 2017-12-12Bibliographically approved

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Odell, Luke R

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