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Regulation of CYP enzymes in steroidogenesis with particular focus on cholesterol metabolism and vitamin D-related processes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Steroid P450)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Steroid P450)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Steroid P450)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Steroid P450)
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2009 (English)In: Proceedings of the 16th International Conference on Cytochrome P450, Nago, Okinawa, Japan, June 21-25 / [ed] Hirofumi Shoun and Hideo Ohkawa, Bologna: Medimond , 2009, 177-182 p.Conference paper, Published paper (Refereed)
Abstract [en]

CYP27A1 is an enzyme essential for cholesterol homeostasis and is considered an anti-atherogenic enzyme. CYP27A1 is required in bile acid biosynthesis and participates in oxysterol formation, cholesterol transport and cholesterol elimination (Fig 1). Considering these important functions, mechanisms for regulation of the human CYP27A1 gene are of great interest (1). CYP27A1 is also a vitamin D 25-hydroxylase, catalyzing the first step in the bioactivation of vitamin D into the multifunctional hormone 1,25-dihydroxyvitamin D. Fig 2 shows the bioactivation of vitamin D. Multiple vitamin D 25-hydroxylases exist in humans. In addition to CYP27A1, other known vitamin D 25-hydroxylases are CYP2R1, CYP2J2 and CYP3A4 (2). The active 1,25-dihydroxyvitamin D is a calcium-regulating hormone. Newly discovered functions of this hormone are regulation of cell growth, regulation of immune function and regulation of blood pressure and insulin production. In the current presentation, we focus on our recent studies on the regulation of CYP27A1 and the CYP enzymes catalyzing the first step in the bioactivation of vitamin D.

Place, publisher, year, edition, pages
Bologna: Medimond , 2009. 177-182 p.
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-124917ISI: 000282798600037ISBN: 978-88-7587-524-4 (print)OAI: oai:DiVA.org:uu-124917DiVA: diva2:318156
Conference
16th International Conference on Cytochrome P450 - Biochemistry, Biophysics, Biotechnology Nago, JAPAN, JUN 21-25, 2009
Available from: 2010-05-06 Created: 2010-05-06 Last updated: 2012-05-31Bibliographically approved

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Wikvall, KjellNorlin, Maria

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