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Reversal of ketamine/xylazine combination anesthesia by atipamezole in olive baboons (Papio anubis)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
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2009 (English)In: Journal of medical primatology, ISSN 0047-2565, E-ISSN 1600-0684, Vol. 38, no 6, 404-410 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The potential of Atipamezole (ATI) to reverse Ketamine/Xylazine (KET/XYL) anesthesia in the Olive baboon (Papio anubis) was studied. METHODS: Anesthesia was induced with 10 mg/kg KET and 0.5 mg/kg XYL intramuscularly. Mean arousal time (MAT), heart rate (HR), systolic arterial blood pressure (SAP), rectal temperature, respiratory rate (RR), and hemoglobin oxygen saturation (SpO(2)) were monitored. Baboons were treated with: KET/XYL only, KET/XYL followed by 100 microg/kg ATI or by 200 microg/kg ATI administered 25 minutes after KET/XYL. RESULTS: Atipamezole rapidly reversed depressed HR and SAP (10 +/- 5.2 minutes), RR (5 +/- 2 minutes) and SpO(2) (3 +/- 6 minutes) and significantly decreased MAT (13 +/- 2.2 minutes) vs. KET/XYL alone (35 +/- 5 minutes). Emesis was absent and salivation was observed after administration of 200 microg/kg ATI only. CONCLUSIONS: Atipamezole at 100 microg/kg is sufficient for rapid and smooth reversal of KET/XYL anesthesia in the Olive baboon with minimal side effects.

Place, publisher, year, edition, pages
2009. Vol. 38, no 6, 404-410 p.
Keyword [en]
animal welfare, Atipamezole, baboon, Ketamine, non-human primate, reversal anesthesia, surgery, Xylazine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-125090DOI: 10.1111/j.1600-0684.2009.00378.xISI: 000271468100004PubMedID: 19735352OAI: oai:DiVA.org:uu-125090DiVA: diva2:318367
Available from: 2010-05-07 Created: 2010-05-07 Last updated: 2017-12-12Bibliographically approved

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