Reversal of ketamine/xylazine combination anesthesia by atipamezole in olive baboons (Papio anubis)
2009 (English)In: Journal of medical primatology, ISSN 0047-2565, E-ISSN 1600-0684, Vol. 38, no 6, 404-410 p.Article in journal (Refereed) Published
BACKGROUND: The potential of Atipamezole (ATI) to reverse Ketamine/Xylazine (KET/XYL) anesthesia in the Olive baboon (Papio anubis) was studied. METHODS: Anesthesia was induced with 10 mg/kg KET and 0.5 mg/kg XYL intramuscularly. Mean arousal time (MAT), heart rate (HR), systolic arterial blood pressure (SAP), rectal temperature, respiratory rate (RR), and hemoglobin oxygen saturation (SpO(2)) were monitored. Baboons were treated with: KET/XYL only, KET/XYL followed by 100 microg/kg ATI or by 200 microg/kg ATI administered 25 minutes after KET/XYL. RESULTS: Atipamezole rapidly reversed depressed HR and SAP (10 +/- 5.2 minutes), RR (5 +/- 2 minutes) and SpO(2) (3 +/- 6 minutes) and significantly decreased MAT (13 +/- 2.2 minutes) vs. KET/XYL alone (35 +/- 5 minutes). Emesis was absent and salivation was observed after administration of 200 microg/kg ATI only. CONCLUSIONS: Atipamezole at 100 microg/kg is sufficient for rapid and smooth reversal of KET/XYL anesthesia in the Olive baboon with minimal side effects.
Place, publisher, year, edition, pages
2009. Vol. 38, no 6, 404-410 p.
animal welfare, Atipamezole, baboon, Ketamine, non-human primate, reversal anesthesia, surgery, Xylazine
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-125090DOI: 10.1111/j.1600-0684.2009.00378.xISI: 000271468100004PubMedID: 19735352OAI: oai:DiVA.org:uu-125090DiVA: diva2:318367