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Serum concentrations of buprenorphine after oral and parenteral administration in male mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
2011 (English)In: The Veterinary Journal, ISSN 1090-0233, E-ISSN 1532-2971, Vol. 187, no 2, 251-254 p.Article in journal (Refereed) Published
Abstract [en]

Buprenorphine is the most commonly used drug for peri-operative pain relief in laboratory rodents. The systemic concentrations of buprenorphine were measured in mice following administration intravenously (IV), subcutaneously (SC), orally by gavage and by voluntary ingestion, to determine the post-administration serum concentration of buprenorphine. Voluntarily ingested buprenorphine resulted in long-lasting high serum concentrations, as did oral gavage administration (24h serum concentration: 110ngh/mL for both routes of administration). In contrast, buprenorphine administered parenterally remained in the circulation for a substantially shorter time (24h serum concentration for IV and SC were 40ngh/mL and 30ngh/mL, respectively). This marked difference was probably due to the higher dose used for oral administration, which is regarded necessary for sufficient analgesic effect, and to the slower absorption of the oral boli, as well as saturation of the hepatic buprenorphine metabolising pathways. Voluntary ingestion of buprenorphine was found to constitute a practical way to provide laboratory mice with efficient pain relief.

Place, publisher, year, edition, pages
2011. Vol. 187, no 2, 251-254 p.
Keyword [en]
Analgesia, Buprenorphine, Kinetics, Refinement, Voluntary ingestion
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-125091DOI: 10.1016/j.tvjl.2009.11.013ISI: 000288520000022PubMedID: 20045358OAI: oai:DiVA.org:uu-125091DiVA: diva2:318368
Available from: 2010-05-07 Created: 2010-05-07 Last updated: 2011-04-04Bibliographically approved

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