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Body weight and faecal corticosterone metabolite excretion in male Sprague-Dawley rats following short transportation and transfer from group-housing to single-housing
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
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2009 (English)In: Scandinavian Journal of Laboratory Animal Science, ISSN 0901-3393, Vol. 36, no 2, p. 205-213Article in journal (Refereed) Published
Abstract [en]

Body weight and faecal excretion of corticosterone metabolites (CM)   were recorded daily in 18 young male Sprague-Dawley rats from the day   they arrived at the animal facility from the breeder. The animals were   group-housed (n=3) and divided in two groups after 7 days. One group   (n=9 animals in 3 cages) was moved to another room in the facility and   the other group remained in the original holding room. After an   additional 7 days the animals which had been moved were separated and   single housed for an additional 7 days. The body weights developed   normally in all rats during the three-week period. Faecal CM excretion   appeared high immediately after the rats arrived from the breeder, and   decreased to reach significantly lower levels 6 days after arrival.   This was likely related to natural fluctuations in faecal CM output   rather than substantial stress. None of the husbandry procedures   performed during the study had any effect on faecal corticosterone   metabolite secretion compared to control. The results suggest that   neither transportation from the breeder, moving within the facility,   nor being transferred from group housing to single housing are events   stressful enough to be reflected by the parameters analysed in the   present study. However, the faecal CM excretions clearly fluctuate over   several days, which must be considered when using faecal samples for   non-invasive stress assessment.

Place, publisher, year, edition, pages
2009. Vol. 36, no 2, p. 205-213
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-125092ISI: 000272409500013OAI: oai:DiVA.org:uu-125092DiVA, id: diva2:318377
Available from: 2010-05-07 Created: 2010-05-07 Last updated: 2017-12-12Bibliographically approved

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