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Separation of amino alcohols using divalent dipeptides as counter ions in aqueous CE
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
2010 (English)In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 31, no 10, 1706-1712 p.Article in journal (Refereed) Published
Abstract [en]

Divalent dipeptides have been introduced as counter ions in aqueous CZE. The dipeptides form ion pairs with amino alcohols in the BGE and facilitate the separation of amino alcohols. High concentrations of dipeptide caused reversed effective mobility for the analytes. The net charge of the dipeptide can be controlled using a buffer or a strong base, and regulates the interaction between the dipeptide and the amino alcohol. A stronger interaction and higher selectivity of amino alcohols was observed when the dipeptides were used as divalent counter ions, than in monovalent or uncharged form. Association constants for ion pairs between divalent dipeptides and amino alcohols can be used to enhance selectivity for amino alcohols in CZE. No chiral separation of amino alcohols was observed when using the dipeptides as ion-pairing chiral selectors in aqueous BGE, but addition of methanol to the BGE promoted enantioselectivity.

Place, publisher, year, edition, pages
2010. Vol. 31, no 10, 1706-1712 p.
Keyword [en]
Association constants, CE, divalent counter ion, Ion-pair formation, reversed mobility
National Category
Medicinal Chemistry
Research subject
Analytical Pharmaceutical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-125470DOI: 10.1002/elps.200900702ISI: 000278650500015PubMedID: 20414882OAI: oai:DiVA.org:uu-125470DiVA: diva2:319700
Available from: 2010-05-19 Created: 2010-05-19 Last updated: 2017-12-12Bibliographically approved

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Haglöf, JakobPettersson, Curt

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