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Malignant giant cell tumor in the posterior fossa of a neonate: case report
Department of Clinical Pathology, University Hospital, Kuopio, Finland.
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2010 (English)In: Journal of Neurosurgery: Pediatrics, ISSN 1933-0707, Vol. 5, no 3, 277-282 p.Article in journal (Refereed) Published
Abstract [en]

Giant cell tumors (GCTs) of the bone are rare, usually benign but locally aggressive neoplasms that primarily occur in the epiphyses of long bones. They seldom develop in the cranium; when they do, they involve principally the sphenoid and temporal bones. These tumors usually affect young adults, and few reports in children have been published. Primary malignant GCTs of the skull are even more uncommon. The 3 published cases all involved adults over 40 years of age. Herein, the authors present a case of a highly aggressive primary malignant GCT of the posterior fossa in a 5-week old preterm infant. One month after the gross-total resection of the tumor found in the bone, the infant's condition rapidly deteriorated and she died. Magnetic resonance imaging and postmortem examination revealed a tumor larger than it had been before the operation, with expansion toward the brain. To the best of the authors' knowledge, this is the youngest patient reported with a primary malignant GCT of the skull, and actually the first case in a pediatric patient. In addition, the extremely high growth rate of the tumor in the postoperative period renders this case the most aggressive primary malignant GCT of the cranium described so far.

Place, publisher, year, edition, pages
2010. Vol. 5, no 3, 277-282 p.
National Category
Cell and Molecular Biology Clinical Laboratory Medicine
Research subject
URN: urn:nbn:se:uu:diva-125520DOI: 10.3171/2009.10.PEDS09453PubMedID: 20192645OAI: oai:DiVA.org:uu-125520DiVA: diva2:319961
Available from: 2010-05-20 Created: 2010-05-20 Last updated: 2014-06-05Bibliographically approved

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Alafuzoff, Irina
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