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Neurobiological aspects of social anxiety disorder
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
2009 (English)In: Israel journal of psychiatry and related sciences, ISSN 0333-7308, Vol. 46, no 1, 5-12 p.Article in journal (Refereed) Published
Abstract [en]

Social anxiety disorder (SAD) has in recent years been widely recognized as a major public health concern. Neurobiologically oriented studies could provide important clues to the causes and cures of this disorder. The present article addresses important findings from neuroimaging and other biological examinations of SAD. Aberrant patterns of brain activity in the amygdala/medial temporal lobe region, insula and striatum are suggested. There is also evidence of abnormalities in the serotonergic and dopaminergic transmission systems. Brain imaging studies have reported reduced serotonin-1A and dopamine D2 receptor binding in certain regions. It is also suggested that serotonin-related gene polymorphisms are important for amygdala responsivity and treatment outcome in SAD.

Place, publisher, year, edition, pages
2009. Vol. 46, no 1, 5-12 p.
National Category
Medical and Health Sciences Psychology
URN: urn:nbn:se:uu:diva-125739ISI: 000282854100002PubMedID: 19728568OAI: oai:DiVA.org:uu-125739DiVA: diva2:320843
Available from: 2010-05-27 Created: 2010-05-27 Last updated: 2010-11-23Bibliographically approved

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