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Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2010 (English)In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 149, no 1, 64-70 p.Article in journal (Refereed) Published
Abstract [en]

Neurokinin 1 (NK1) receptors are involved in pain and anxiety behaviors in animals, but little is known about central alterations in this receptor system in human pain. With positron emission tomography, using a [11]-Carbon labeled NK1 receptor antagonist, we demonstrate attenuated NK1 receptor availability in frontal, insular and cingulate cortex, as well as the hippocampus, amygdala and the periaqueductal gray area in patients with chronic pain. The reduced availability was most pronounced in the ventromedial prefrontal cortex (vmPFC), where attenuations correlated to measures of fear and avoidance of movement. Further, vmPFC NK1 levels also displayed opposing influences in patients as compared to controls on regional cerebral blood flow in the anterior cingulate. We conclude that the central NK1 receptor system is altered in human chronic pain. The results suggest that NK1 receptors in the vmPFC modulate motor inhibition, and contribute to fear and avoidance of movement.

Place, publisher, year, edition, pages
2010. Vol. 149, no 1, 64-70 p.
Keyword [en]
Avoidance, Chronic pain, Neurokinin 1, PET, Substance P, Ventromedial prefrontal cortex, Whiplash
National Category
Medical and Health Sciences Psychology
Identifiers
URN: urn:nbn:se:uu:diva-125747DOI: 10.1016/j.pain.2010.01.008ISI: 000275789500012PubMedID: 20137858OAI: oai:DiVA.org:uu-125747DiVA: diva2:320893
Available from: 2010-05-27 Created: 2010-05-27 Last updated: 2012-03-12Bibliographically approved

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Appel, LieuweFurmark, TomasFredrikson, Mats

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Department of PsychologySection of Nuclear Medicine and PETDepartment of NeuroscienceAnaesthesiology and Intensive CareDepartment of Biochemistry and Organic Chemistry
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Pain
Medical and Health SciencesPsychology

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