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Myeloid leukaemia in systemic lupus erythematosus--a nested case-control study based on Swedish registers
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Christer Sundström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Christer Sundström)
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2009 (English)In: Rhematology Int, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 48, no 10, 1222-1226 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To assess the risk factors for leukaemic transformation and myeloid leukaemia in patients with SLE. METHODS: A national SLE cohort identified through SLE discharge diagnoses in the Swedish hospital discharge register during 1964 to 1995 (n = 6438) was linked to the national cancer register. A nested case-control study in SLE patients who developed acute or chronic myeloid leukaemia was performed with SLE patients without malignancy as controls. Medical records from cases and controls were reviewed and bone marrow specimens were re-evaluated. A Medline search of previously published cases of SLE and myeloid leukaemia was performed. RESULTS: After confirmation of SLE diagnosis according to the ACR criteria, eight patients with SLE and myeloid leukaemia and 18 SLE controls were included in the study. Preceding leucopenia was significantly associated with leukaemia development, whereas other SLE manifestations were not. Two cases had a preceding bone marrow confirming myelodysplastic syndrome (MDS). Only two cases were significantly treated with cyclophosphamide or AZA. A Medline search resulted in only 15 previously published cases of coincident SLE and myeloid leukaemia. Preceding MDS was reported in five of these, whereas only eight had been treated with cytotoxic drugs. CONCLUSION: Low-dose chemotherapy was not a major cause of myeloid malignancy in our population-based cohort of SLE patients nor in the reported cases from literature. Leucopenia was a risk factor for myeloid leukaemia development and an MDS was frequently seen. Therefore bone marrow investigation should be considered in SLE patients with long-standing leucopenia and anaemia.

Place, publisher, year, edition, pages
2009. Vol. 48, no 10, 1222-1226 p.
Keyword [en]
Systemic lupus erythematosus, Acute myeloid leukaemia, Myelodysplastic syndrome, Risk factors, Leucopenia, Cytotoxic drugs
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:uu:diva-125758DOI: 10.1093/rheumatology/kep204ISI: 000270267600011PubMedID: 19608725OAI: oai:DiVA.org:uu-125758DiVA: diva2:320991
Available from: 2010-05-28 Created: 2010-05-28 Last updated: 2010-07-02Bibliographically approved

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