uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Adjuvant tamoxifen in breast cancer patients affects the endometrium by time, an effect remaining years after end of treatment and results in an increased frequency of endometrial carcinoma
Show others and affiliations
2008 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 28, no 2B, 1259-1262 p.Article in journal (Refereed) Published
Abstract [en]

Tamoxifen is the most used adjuvant drug in breast cancer treatment. Its main action is as an anti-oestrogen, but in the endometrium of some patients it acts as an oestrogen. Some investigators have even reported an increased risk of developing endometrial carcinoma. The question of how to follow-up these patients and how to identify patients at risk of developing endometrial premalignant changes was investigated by the noninvasive ultrasound method. The follow-up of 292 patients from before the start of adjuvant treatment with tamoxifen and 94 without tamoxifen treatment was conducted at regular intervals. The changes in endometrial thickness as measured by ultrasound and histopathological changes are reported. A thicker endometrium was found in patients with receptor positive breast cancer even before the treatment with tamoxifen started. Cumulative increasing thickness was found during treatment and this thicker endometrium remained until almost 3 years after the end of treatment. If the endometrium was <3 mm after 3 months of treatment the probability that it would be thin after 5 years was high. An increased risk of developing endometrial carcinoma was found, however due to this regular follow-up the cancer was identified at an early stage.

Place, publisher, year, edition, pages
2008. Vol. 28, no 2B, 1259-1262 p.
Keyword [en]
Tamofixen, breat cancer, endometiral carcinoma
National Category
Obstetrics, Gynecology and Reproductive Medicine Cell and Molecular Biology
Research subject
Pathology; Obstetrics and Gynaecology
URN: urn:nbn:se:uu:diva-125821ISI: 000255254300016PubMedID: 18505063OAI: oai:DiVA.org:uu-125821DiVA: diva2:321063
Available from: 2010-05-28 Created: 2010-05-28 Last updated: 2011-04-25Bibliographically approved

Open Access in DiVA

No full text

By organisation
Department of Genetics and Pathology
In the same journal
Anticancer Research
Obstetrics, Gynecology and Reproductive MedicineCell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 197 hits
ReferencesLink to record
Permanent link

Direct link