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Value of high-risk HPV-DNA testing in the triage of ASCUS
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Hellström Pigg)
2009 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 88, no 9, 1006-1010 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE. Atypical squamous cells of undetermined significance (ASCUS) cells, occurring in organized cytological screening, may be either high-risk human papillomavirus (HPV) positive or negative. To refine the assessment of women with ASCUS, a high-risk HPV-DNA test is recommended as triage in Sweden. METHODS: A total of 197 consecutive women (mean age 39 years, range 21-60) with a diagnosis of ASCUS from the primary screening were selected for triage. Their cervical smears were collected and evaluated by using conventional cytological examination in combination with a high-risk HPV-DNA test (hybrid capture 2). The women were categorized into four groups: Group A, Cytology + /HPV + ; Group B, Cytology-/HPV + ; Group C, Cytology + /HPV-; and Group D, Cytology-/ HPV-. Women within Groups A-C were admitted for colposcopy and cervical biopsy. The women in Group D were considered as a low-risk group for tumor development, and were re-examined after three years in the next round of the organized screening. RESULTS: In women in Group A (n=58) the prevalence of histological verified CIN2-3 was 41%, in Group B (n=41) 20%, and in Group C (n=9) 0%. In Group D (n=89), repeated primary screening three years later revealed CIN2-3 in two biopsies from 74 women studied (<3%). The prevalence of a high-risk HPV infection decreased with age in women with ASCUS. It was 74% in women <30 years and 19% in women > or =50 years. CONCLUSIONS: Adding a high-risk HPV test in secondary screening increased the identification of women with CIN2-3 lesions by 33% in comparison with repeat cytology (p=0.01). The clinical significance of the ASCUS diagnosis varied with age of the women.

Place, publisher, year, edition, pages
2009. Vol. 88, no 9, 1006-1010 p.
Keyword [en]
National Category
Obstetrics, Gynecology and Reproductive Medicine Obstetrics, Gynecology and Reproductive Medicine Cell and Molecular Biology
Research subject
Obstetrics and Gynaecology; Pathology
URN: urn:nbn:se:uu:diva-125833DOI: 10.1080/00016340903160952PubMedID: 19690991OAI: oai:DiVA.org:uu-125833DiVA: diva2:321070
Available from: 2010-05-28 Created: 2010-05-28 Last updated: 2010-07-13Bibliographically approved

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Acta Obstetricia et Gynecologica Scandinavica
Obstetrics, Gynecology and Reproductive MedicineObstetrics, Gynecology and Reproductive MedicineCell and Molecular Biology

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