uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth
Show others and affiliations
2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 9, 3414-3419 p.Article in journal (Refereed) Published
Abstract [en]

This study explored the role of secreted fibroblast-derived factors in prostate cancer growth. Analyses of matched normal and tumor tissue revealed up-regulation of CXCL14 in cancer-associated fibroblasts of a majority of prostate cancer. Fibroblasts over-expressing CXCL14 promoted the growth of prostate cancer xenografts, and increased tumor angiogenesis and macrophage infiltration. Mechanistic studies demonstrated that autocrine CXCL14-stimulation of fibroblasts stimulate migration and ERK-dependent proliferation of fibroblasts. CXCL14-stimulation of monocyte migration was also demonstrated. Furthermore, CXCL14-producing fibroblasts, but not recombinant CXCL14, enhanced in vitro proliferation and migration of prostate cancer cells and in vivo angiogenesis. These studies thus identify CXCL14 as a novel autocrine stimulator of fibroblast growth and migration, with multi-modal tumor-stimulatory activities. In more general terms, our findings suggest autocrine stimulation of fibroblasts as a previously unrecognized mechanism for chemokine-mediated stimulation of tumor growth, and suggest a novel mechanism whereby cancer-associated fibroblasts achieve their pro-tumorigenic phenotype.

Place, publisher, year, edition, pages
2009. Vol. 106, no 9, 3414-3419 p.
Keyword [en]
CXCL14, cancer-associated fibroblasts, prostate cancer, tumor stroma
National Category
Cell and Molecular Biology Cell and Molecular Biology Urology and Nephrology
Research subject
Pathology; Molecular Medicine
URN: urn:nbn:se:uu:diva-125851DOI: 10.1073/pnas.0813144106ISI: 000263844100078PubMedID: 19218429OAI: oai:DiVA.org:uu-125851DiVA: diva2:321089
Available from: 2010-05-28 Created: 2010-05-28 Last updated: 2010-08-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Genetics and Pathology
In the same journal
Proceedings of the National Academy of Sciences of the United States of America
Cell and Molecular BiologyCell and Molecular BiologyUrology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 188 hits
ReferencesLink to record
Permanent link

Direct link