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Regulation of tyrosine phosphatases in the adventitia during vascular remodelling
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Botling)
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2009 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 382, no 4, 678-684 p.Article in journal (Refereed) Published
Abstract [en]

Protein tyrosine phosphatases (PTPs) are regulators of growth factor signalling in vascular remodelling. The aim of this study was to evaluate PTP expression in the context of PDGF-signalling in the adventitia after angioplasty. Utilising a rat carotid artery model, the adventitial layers of injured and non-injured vessels were laser microdissected. The mRNA expression of the PDGF beta-receptor, the ligands PDGF-A/B/C/D and the receptor-antagonising PTPs (DEP-1, TC-PTP, SHP-2, PTP1B) were determined and correlated to vascular morphometrics, proliferation markers and PDGF beta-receptor phosphorylation. The levels of the PDGF beta-receptor, PDGF-C and PDGF-D were upregulated concurrently with the antagonising PTPs DEP-1 and TC-PTP at day 8, and normalised at day 14 after vessel injury. Although the proliferation parameters were time-dependently altered in the adventitial layer, the phosphorylation of the PDGF beta-receptor remained unchanged. The expression dynamics of specific PTPs indicate a regulatory role of PDGF-signalling also in the adventitia during vascular remodelling.

Place, publisher, year, edition, pages
2009. Vol. 382, no 4, 678-684 p.
Keyword [en]
adventitia, tyrosine
National Category
Medical Genetics Cell and Molecular Biology
Research subject
Molecular Medicine; Pathology
Identifiers
URN: urn:nbn:se:uu:diva-125853DOI: 10.1016/j.bbrc.2009.03.078ISI: 000265989200008PubMedID: 19302976OAI: oai:DiVA.org:uu-125853DiVA: diva2:321090
Available from: 2010-05-28 Created: 2010-05-28 Last updated: 2017-12-12Bibliographically approved

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