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Altered NK1-receptor availability in patients with post traumatic stress disorder
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
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2009 (English)In: [Biological Psychiatry 2009, 65(8), Suppl. 1, 118S, no. 394], 2009, 118S- p.Conference paper, Published paper (Refereed)
Abstract [en]

Background: Posttraumatic stress disorder (PTSD) is an anxiety disorder that can develop after one or more traumatic events causing extreme stress or grave physical harm. The neurokinin-1 (NK1) receptor is the primary receptor for substance P (SP); a neuropeptide suggested being involved in anxiety and depression. The present study investigated differences in NK1-receptor availability between PTSD patients and healthy controls, using positron emission tomography (PET). Methods: Eleven male refugee patients (age: 41±10) with DSM-IV defined PTSD and nine healthy male control subjects (age: 33±10) were investigated using the PET-tracer [11C]GR205171, supplied by Uppsala Imanet. GR205171 is a highly selective NK1-receptor antagonist. Scans were performed during 60 minutes in the resting state. Parametric images were generated using the graphical reference Patlak method assuming irreversible binding of [11C]GR205171 from 20-60 minutes and having cerebellum as reference region. Exploratory whole brain analyses were performed using the statistical parametric mapping (SPM2) software. Results: PTSD patients had lower [11C]GR205171 binding compared to controls, in frontal cortical clusters encompassing bilaterally insula and left Brodmann area 11, reflecting lower NK1-receptor availability. No areas were found in which PTSD patients had higher [11C]GR205171 binding. Conclusions: This is the first study reporting differences in NK1-receptor availability in PTSD patients relative to controls. A tentative conclusion is that PTSD patients have a down regulation of the NK1-receptor system, which could be either a risk factor or due to emotional trauma processing.

Place, publisher, year, edition, pages
2009. 118S- p.
National Category
Psychiatry Psychology
Identifiers
URN: urn:nbn:se:uu:diva-125878DOI: 10.1016/j.biopsych.2009.03.002OAI: oai:DiVA.org:uu-125878DiVA: diva2:321151
Conference
Sixty-Fourth Annual Convention and Scientific Program
Available from: 2010-05-28 Created: 2010-05-28 Last updated: 2011-01-11Bibliographically approved

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Appel, LieuweMichelgård, ÅsaFernandez, ManuelFurmark, Tomasvon Knorring, LarsFredrikson, Mats

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Appel, LieuweMichelgård, ÅsaFernandez, ManuelFurmark, Tomasvon Knorring, LarsFredrikson, Mats
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Department of Oncology, Radiology and Clinical ImmunologyPsychiatry, University HospitalDepartment of Psychology
PsychiatryPsychology

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