The effects of medial temporal lobe resections on verbal threat and fear conditioning
2010 (English)In: Biological Psychology, ISSN 0301-0511, E-ISSN 1873-6246, Vol. 83, no 1, 41-46 p.Article in journal (Refereed) Published
A left hemisphere advantage in the processing of verbal threat has previously been reported, whereas both hemispheres seem equally important in fear conditioning. Here, we compared the effects of unilateral medial temporal lobe (MTL) resections on verbal threat as well as delay and trace fear conditioning. During verbal threat, right and left MTL-resections attenuated fear potentiated startle in comparison with controls. In contrast to previous studies, MTL-resections did not attenuate delay conditioning of skin conductance responses. Left and right resectioned patients did not differ in psychophysiological responses to verbal threat or delay fear conditioning. Trace conditioning was not observed in any group. Results suggest a bilateral MTL hemispheric involvement in the processing of verbal threat, whereas one intact hemisphere seems sufficient for delay conditioning.
Place, publisher, year, edition, pages
2010. Vol. 83, no 1, 41-46 p.
Amygdala; Anxiety; Startle; Electrodermal activity; Temporal lobectomy; Trace conditioning
IdentifiersURN: urn:nbn:se:uu:diva-125908DOI: 10.1016/j.biopsycho.2009.10.002ISI: 000273944000007PubMedID: 19836434OAI: oai:DiVA.org:uu-125908DiVA: diva2:321252
Correction in: Biological Psychology, 2010, vol. 83, issue 3, p. 272, doi: 10.1016/j.biopsycho.2009.12.004 2010-05-312010-05-312010-12-21Bibliographically approved