uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Interaction of N,N,N-trialkylammonioundecahydro-closo-dodecaborates with dipalmitoyl phosphatidylcholine liposomes
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
Show others and affiliations
2010 (English)In: Chemistry and Physics of Lipids, ISSN 0009-3084, E-ISSN 1873-2941, Vol. 163, no 1, 64-73 p.Article in journal (Refereed) Published
Abstract [en]

N,N,N-Trialkylammonioundecahydrododecaborates (1-), a novel class of compounds of interest for use as anions in ionic liquids, interact with DPPC liposomes. Increasing compound concentration causes an increasing negative zeta potential. Dissociation constants demonstrate that the binding capacity increases strongly with longer chain length. N,N,N-Trialkylammonioundecahydrododecaborates with longer alkyl chains show a detergent-like behavior: the compounds incorporate into the liposome membrane and differential scanning calorimetric experiment show already low concentrations cause a complete disappearance of the peak representing the gel-to-liquid crystalline phase transition. In contrast, compounds with shorter alkyl chains only interact with the headgroups of the lipids. Investigations by means of cryo-TEM reveal that all derivatives induce significant morphological changes of the liposomes. N,N,N-Trialkylammonioundecahydrododecaborates with short alkyl chains produce large bilayer sheets, whereas those with longer alkyl chains tend to induce the formation of open or multi-layered liposomes. We propose that the binding of N,N,N-trialkylammonioundecahydrododecaborates is mainly due to electrostatic interactions between the doubly negatively charged cluster unit and the positively charged choline headgroup; the positively charged ammonium group might be in contact with the deeper-lying negatively charged phosphate. For N,N,N-trialkylammonioundecahydrododecaborates with longer alkyl chains hydrophobic interactions with the non-polar hydrocarbon part of the membrane constitute an additional important driving force for the association of the compounds to the lipid bilayer.

Place, publisher, year, edition, pages
2010. Vol. 163, no 1, 64-73 p.
Keyword [en]
Liposomes, Ionic liquids, cryo-TEM, Differential scanning calorimetry, Fusion, Leakage
National Category
Other Basic Medicine
URN: urn:nbn:se:uu:diva-125920DOI: 10.1016/j.chemphyslip.2009.09.004ISI: 000274055800007PubMedID: 19800875OAI: oai:DiVA.org:uu-125920DiVA: diva2:321332
Available from: 2010-05-31 Created: 2010-05-31 Last updated: 2011-03-31Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Karlsson, GöranEdwards, Katarina
By organisation
Physical Chemistry
In the same journal
Chemistry and Physics of Lipids
Other Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 407 hits
ReferencesLink to record
Permanent link

Direct link