Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein
2008 (English)In: Annals of Neurology, ISSN 0364-5134, E-ISSN 1531-8249, Vol. 64, no 3, 348-352 p.Article in journal (Refereed) Published
We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration.
Place, publisher, year, edition, pages
2008. Vol. 64, no 3, 348-352 p.
Neurology Cell and Molecular Biology
Research subject Pathology; Neurology
IdentifiersURN: urn:nbn:se:uu:diva-126008DOI: 10.1002/ana.21446PubMedID: 18661559OAI: oai:DiVA.org:uu-126008DiVA: diva2:321617