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Serum amyloid A and protein AA: molecular mechanisms of a transmissible amyloidosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Per Westermark)
2009 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 583, no 16, 2685-2690 p.Article, review/survey (Refereed) Published
Abstract [en]

Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils. Systemic AA-amyloidosis is transmissible in mice and may be so in humans. Since transmission can cross species barriers it is possible that AA-amyloidosis can be induced by amyloid in food, e.g. foie gras. In mice, development of AA-amyloidosis can also be accelerated by other components with amyloid-like properties. A new possible risk factor may appear with synthetically made fibrils from short peptides, constructed for tissue repair.

Place, publisher, year, edition, pages
2009. Vol. 583, no 16, 2685-2690 p.
Keyword [en]
Amyloid; Fibril; Prion; Transmission; Seeding
National Category
Dermatology and Venereal Diseases Cell and Molecular Biology
Research subject
Pathology
Identifiers
URN: urn:nbn:se:uu:diva-126019DOI: 10.1016/j.febslet.2009.04.026ISI: 000269836900015PubMedID: 19393650OAI: oai:DiVA.org:uu-126019DiVA: diva2:321630
Available from: 2010-06-01 Created: 2010-06-01 Last updated: 2017-12-12Bibliographically approved

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