Serum amyloid A and protein AA: molecular mechanisms of a transmissible amyloidosis
2009 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 583, no 16, 2685-2690 p.Article, review/survey (Refereed) Published
Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils. Systemic AA-amyloidosis is transmissible in mice and may be so in humans. Since transmission can cross species barriers it is possible that AA-amyloidosis can be induced by amyloid in food, e.g. foie gras. In mice, development of AA-amyloidosis can also be accelerated by other components with amyloid-like properties. A new possible risk factor may appear with synthetically made fibrils from short peptides, constructed for tissue repair.
Place, publisher, year, edition, pages
2009. Vol. 583, no 16, 2685-2690 p.
Amyloid; Fibril; Prion; Transmission; Seeding
Dermatology and Venereal Diseases Cell and Molecular Biology
Research subject Pathology
IdentifiersURN: urn:nbn:se:uu:diva-126019DOI: 10.1016/j.febslet.2009.04.026ISI: 000269836900015PubMedID: 19393650OAI: oai:DiVA.org:uu-126019DiVA: diva2:321630