Acute effects of exposure to 1 mg/m(3) of vaporized 2-ethyl-1-hexanol in humans
2010 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, Vol. 20, no 2, 168-175 p.Article in journal (Refereed) Published
The objective was to assess acute effects from controlled exposure of volunteers to 2-ethyl-1-hexanol, a volatile organic compound that is often found in indoor air. Sixteen males and fourteen females were in random order exposed to 1 mg/m3 of vapors of 2-ethyl-1-hexanol or to clean air (control exposure) in an exposure chamber during 2 h at rest. The subjects performed symptom ratings on Visual Analog Scales. During exposure to 2-ethyl-1-hexanol subjective ratings of smell and eye discomfort were minimally but significantly increased. Ratings of nasal irritation, throat irritation, headache, dyspnoea, fatigue, dizziness, nausea, and intoxication were not significantly affected. No exposure-related effects on measurement of blinking frequency by electromyography, measurement of the eye break-up time, vital staining of the eye, nasal lavage biomarkers, transfer tests, spirometric and rhinometric measures were seen. No differences in response were seen between sexes or between atopics and non-atopics
Place, publisher, year, edition, pages
2010. Vol. 20, no 2, 168-175 p.
2-Ethyl-1-hexanol, Chamber study, Eye and Upper airway irritation, Indoor environment, Volatile organic compound
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-126602DOI: 10.1111/j.1600-0668.2009.00638.xISI: 000275886900008PubMedID: 20409194OAI: oai:DiVA.org:uu-126602DiVA: diva2:325319