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Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology.
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2009 (English)In: Genes & Development, ISSN 0890-9369, E-ISSN 1549-5477, Vol. 23, no 22, 2598-2603 p.Article in journal (Refereed) Published
Abstract [en]

Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.

Place, publisher, year, edition, pages
2009. Vol. 23, no 22, 2598-2603 p.
Keyword [en]
Transvection, imprinting, epigenetics, replication timing, H19 ICR
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-127421DOI: 10.1101/gad.552109ISI: 000271803900004OAI: oai:DiVA.org:uu-127421DiVA: diva2:329913
Available from: 2010-07-14 Created: 2010-07-13 Last updated: 2017-12-12Bibliographically approved

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