uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Show others and affiliations
2009 (English)In: Nature, ISSN 0028-0836, Vol. 460, no 7256, 748-752 p.Article in journal (Refereed) Published
Abstract [en]

Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%(1,2). We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.

Place, publisher, year, edition, pages
2009. Vol. 460, no 7256, 748-752 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-128329DOI: 10.1038/nature08185ISI: 000268670300041OAI: oai:DiVA.org:uu-128329DiVA: diva2:331271
Available from: 2010-07-22 Created: 2010-07-20 Last updated: 2010-07-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Neuroscience
In the same journal
Nature
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 412 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf