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Closing gaps in the human genome using sequencing by synthesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2009 (English)In: Genome Biology, ISSN 1474-760X, Vol. 10, no 6, R60- p.Article in journal (Refereed) Published
Abstract [en]

The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15.

Place, publisher, year, edition, pages
2009. Vol. 10, no 6, R60- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-128396DOI: 10.1186/gb-2009-10-6-r60ISI: 000267604300010OAI: oai:DiVA.org:uu-128396DiVA: diva2:331522
Available from: 2010-07-23 Created: 2010-07-20 Last updated: 2010-07-23Bibliographically approved

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