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Methylene blue, an old drug with new indications?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2010 (English)In: Jurnalul Roman de Anestezie Terapie Intaensiva, ISSN 1582-652X, Vol. 17, no 1, 35-41 p.Article, review/survey (Other academic) Published
Abstract [en]

Just when we thought we finally understood methylene blue (MB) after it has been used clinically for more than a century, the old properties are revived and therefore possible new indications appears. Nitric oxide (NO) stimulates soluble guanylate cyclase, which converts guanosine triphosphate into cyclic guanosine monophosphate. Increases in cGMP concentration, in turn, through a cascade of protein kinases, induce smooth muscle relaxation and vasodilation. Methylene blue (MB) has direct inhibitory effects on nitric oxide synthases (NOS), both constitutive and inducible and blocks accumulation of cyclic guanosine monophosphate (cGMP) by inhibiting the enzyme guanylate cyclase. Also, MB blocks the iron-containing enzymes such as xanthine oxidase and has antioxidants effects. New indications are therefore described in relation with MB as in the vasoplegic syndrome following cardiopulmonary bypass in humans and in the settings of cardiac arrest in animals.

Place, publisher, year, edition, pages
2010. Vol. 17, no 1, 35-41 p.
Keyword [en]
methylene blue, oxidative injury, neuroprotection, hemodynamics, cardiopulmonary resuscitation
Keyword [un]
albastru de metilen, leziune oxidativă, neuroprotecţie, hemodinamică, resuscitare cardiopulmonară
National Category
Anesthesiology and Intensive Care
Research subject
Anaesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:uu:diva-128811OAI: oai:DiVA.org:uu-128811DiVA: diva2:331724
Note
Romanian journalAvailable from: 2010-07-26 Created: 2010-07-24 Last updated: 2010-08-19Bibliographically approved

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Miclescu, AdrianaWiklund, Lars

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