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DTNBP1, NRG1, DAOA, DAO and GRM3 Polymorphisms and Schizophrenia: An Association Study
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2009 (English)In: Neuropsychobiology, ISSN 0302-282X, E-ISSN 1423-0224, Vol. 59, no 3, 142-150 p.Article in journal (Refereed) Published
Abstract [en]

Background: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. Methods: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. Results: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. Conclusions: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships. Copyright (C) 2009 S. Karger AG, Basel

Place, publisher, year, edition, pages
2009. Vol. 59, no 3, 142-150 p.
Keyword [en]
Dysbindin gene, Neuregulin 1, D-amino-acid oxidase gene, D-amino-acid oxidase activator, Metabotropic glutamate receptor 3, Single-nucleotide polymorphisms, Schizophrenia
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-129031DOI: 10.1159/000218076ISI: 000266343600002OAI: oai:DiVA.org:uu-129031DiVA: diva2:337481
Available from: 2010-08-06 Created: 2010-08-05 Last updated: 2010-08-06Bibliographically approved

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