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Cross-sectional analysis of testosterone therapies in hypopituitary men on stable pituitary hormone replacement
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2009 (English)In: Clinical Endocrinology, ISSN 0300-0664, E-ISSN 1365-2265, Vol. 70, no 6, 907-913 p.Article in journal (Refereed) Published
Abstract [en]

The last decade has seen a proliferation in options for testosterone replacement. However, little is known as to the benefits of different treatment modalities. Our objective was to determine the testosterone prescription pattern and to examine the impact on various outcome measures. A total of 816 adult-onset hypopituitary males on stable pituitary replacement for at least 1 year were identified from the KIMS database. Patients were classified as either eugonadal (n = 106), or hypogonadal (n = 710) on intramuscular (IM, n = 558), oral (n = 74), transdermal (n = 61), and depot (n = 17) testosterone. After 1 year of stable pituitary replacement therapy, body composition, cardiovascular parameters, GH replacement and quality of life were not significantly different in androgen-replaced hypogonadal patients compared to eugonadal patients. There were no differences in outcome variables within the hypogonadal group according to the testosterone replacement regimen used and no difference in response to GH therapy. The majority of hypopituitary patients in the last decade have received IM testosterone. Body composition, cardiovascular parameters, GH replacement and quality of life were not different between eugonadal and hypogonadal patients and were not differentially affected by the mode of testosterone replacement. These findings are reassuring that there is no major difference in response to different testosterone replacement regimens.

Place, publisher, year, edition, pages
2009. Vol. 70, no 6, 907-913 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-129071DOI: 10.1111/j.1365-2265.2008.03435.xISI: 000266015400013OAI: oai:DiVA.org:uu-129071DiVA: diva2:337541
Available from: 2010-08-06 Created: 2010-08-05 Last updated: 2010-08-06Bibliographically approved

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