uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Anti-Amyloid Activity of the C-Terminal Domain of proSP-C against Amyloid beta-Peptide and Medin
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Show others and affiliations
2009 (English)In: Biochemistry, ISSN 0006-2960, E-ISSN 1520-4995, Vol. 48, no 17, 3778-3786 p.Article in journal (Refereed) Published
Abstract [en]

Amyloid fibrils are found in similar to 25 different diseases, including Alzheimer's disease. Lung surfactant protein C (SP-C) forms fibrils in association with pulmonary disease. It was recently found that the C-terminal domain of proSP-C (CTC), which is localized to the endoplasmic reticulum (ER) lumen, protects the transmembrane (TM) part of (pro)SP-C from aggregation into amyloid until it has a folded into an alpha-helix. CTC appears to have a more general anti-amyloid effect by also acting on TM regions of other proteins. Here we investigate interactions of CTC with the amyloid beta-peptide (A beta) associated with Alzheimer's disease and medin, a peptide that forms fibrils in the most common form of human amyloid. CTC prevents fibril formation in A beta and medin and forms a complex with A beta oligomers, as judged by size-exclusion chromatography and electrospray ionization mass spectrometry. These data suggest that CTC functions as a chaperone that acts preferentially against unfolded TM segments and structural motifs found during amyloid fibril formation, a mechanism that may be exploited in forming a basis for future anti-amyloid therapy.

Place, publisher, year, edition, pages
2009. Vol. 48, no 17, 3778-3786 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-129095DOI: 10.1021/bi900135cISI: 000265528800009PubMedID: 19281242OAI: oai:DiVA.org:uu-129095DiVA: diva2:337570
Available from: 2010-08-06 Created: 2010-08-05 Last updated: 2011-03-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Genetics and Pathology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 124 hits
ReferencesLink to record
Permanent link

Direct link