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Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Biochemistry.
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2006 (English)In: Pharmazie, ISSN 0031-7144, E-ISSN 0031-7144, Vol. 61, no 8, 717-721 p.Article in journal (Refereed) Published
Abstract [en]

In order to identify novel lead compounds with antiviral effect, methanol and aqueous extracts of eight medicinal plants in the Zingiberaceae family were screened for inhibition of proteases from human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and human cytomegalovirus (HCMV). In general, the methanol extracts inhibited the enzymes more effectively than the aqueous extracts. HIV-1 protease was strongly inhibited by the methanol extract of Alpinia galanga. This extract also inhibited HCV and HCMV proteases, but to a lower degree. HCV protease was most efficiently inhibited by the extracts from Zingiber officinale, with little difference between the aqueous and the methanol extracts. Many of the methanol extracts inhibited HCMV protease, but the aqueous extracts showed weak inhibition. In a first endeavor to identify the active constituents, eight flavones were isolated from the black rhizomes of Kaempferia parviflora. The most effective inhibitors, 5-hydroxy-7-methoxyflavone and 5,7-dimethoxyflavone, inhibited HIV-1 protease with IC50 values of 19 microM. Moreover, 5-hydroxy-3,7-dimethoxyflavone inhibited HCV protease and HCMV protease with IC50 values of 190 and 250 microM, respectively.

Place, publisher, year, edition, pages
2006. Vol. 61, no 8, 717-721 p.
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-121196ISI: 000239907900016PubMedID: 16964717OAI: oai:DiVA.org:uu-121196DiVA: diva2:343681
Available from: 2010-08-15 Created: 2010-03-18 Last updated: 2010-11-16Bibliographically approved

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