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Botulinum toxin in the treatment of sweat-worsened foot problems in patients with epidermolysis bullosa simplex and pachyonychia congenita
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Research and Development, Gävleborg.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
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2010 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 163, no 5, 1072-1076 p.Article in journal (Refereed) Published
Abstract [en]

Background: Painful foot blistering is a common problem in patients with epidermolysis bullosa simplex (EBS) and pachyonychia congenita (PC). Hyperhidrosis, a condition which can be effectively blocked by plantar injections of botulinum toxin (Btx), often exacerbates the blistering. Objectives: A retrospective evaluation of the effects of Btx injections in 14 EBS and PC patients with foot blisters and painful callosities. Patients/methods: After informed consent, patients with EBS (n=6) and PC (n=8), aged 7-66 years, who had received Btx therapy at our centre since 2003, were included. The treatment consisted of multiple plantar injections of Btx A or Btx B after prior regional or general anaesthesia. Patients were interviewed about the treatment effect and were asked to score the improvement from 0-5, where 5 is 'excellent'. One PC patient with painful callosities was studied by magnetic resonance (MR) spectroscopic micro-imaging technique before and after Btx injections to disclose any underlying blisters. Results: A total of 76 treatments were evaluated (1-19 sessions/patient). Thirteen patients (92.8%) reported reduced plantar blistering and pain; the improvement score was >/=4 in 4/6 EBS patients and 6/8 PC patients. The mean effect duration was 3 months. No adverse events, apart from mild anti-cholinergic side-effects in 2 patients, were noted. MR spectroscopic micro-imaging showed disappearance of intraepidermal blistering after Btx therapy. Conclusions: Plantar injection of Btx is an efficient, long-lasting and safe treatment of painful blistering and callosities in EBS and PC that can be given repeatedly without loss of efficacy.

Place, publisher, year, edition, pages
2010. Vol. 163, no 5, 1072-1076 p.
Keyword [en]
blisters, botulinum toxin, callus, epidermolytic disorders, hyperhidrosis, keratin mutation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-129497DOI: 10.1111/j.1365-2133.2010.09927.xISI: 000283597500025PubMedID: 20618323OAI: oai:DiVA.org:uu-129497DiVA: diva2:344030
Available from: 2010-08-17 Created: 2010-08-17 Last updated: 2017-12-12Bibliographically approved

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