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Applying the genetic theories of ageing to the cytoplasm: cytoplasmic genetic covariation for fitness and lifespan
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Evolution. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
2009 (English)In: Journal of Evolutionary Biology, ISSN 1010-061X, E-ISSN 1420-9101, Vol. 22, no 4, 818-827 p.Article in journal (Refereed) Published
Abstract [en]

Two genetic models exist to explain the evolution of ageing - mutation accumulation (MA) and antagonistic pleiotropy (AP). Under MA, a reduced intensity of selection with age results in accumulation of late-acting deleterious mutations. Under AP, late-acting deleterious mutations accumulate because they confer beneficial effects early in life. Recent studies suggest that the mitochondrial genome is a major player in ageing. It therefore seems plausible that the MA and AP models will be relevant to genomes within the cytoplasm. This possibility has not been considered previously. We explore whether patterns of covariation between fitness and ageing across 25 cytoplasmic lines, sampled from a population of Drosophila melanogaster, are consistent with the genetic associations predicted under MA or AP. We find negative covariation for fitness and the rate of ageing, and positive covariation for fitness and lifespan. Notably, the direction of these associations is opposite to that typically predicted under AP.

Place, publisher, year, edition, pages
2009. Vol. 22, no 4, 818-827 p.
Keyword [en]
ageing, antagonistic pleiotropy, cytoplasm, Drosophila melanogaster, mitochondria, mtDNA, mutation accumulation, senescence
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-129875DOI: 10.1111/j.1420-9101.2009.01692.xISI: 000264186000015OAI: oai:DiVA.org:uu-129875DiVA: diva2:345540
Available from: 2010-08-25 Created: 2010-08-25 Last updated: 2016-04-18Bibliographically approved

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Maklakov, A. A.
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