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Histological Inflammatory Response to Transvaginal Polypropylene Mesh for Pelvic Reconstructive Surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
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2009 (English)In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 181, no 3, 1189-1195 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: We prospectively evaluated the histological inflammatory response to the large polypropylene transvaginal mesh used for pelvic organ prolapse surgery. Materials and Methods: Ten patients and 8 controls underwent vaginal punch biopsy sampling before surgery and patients also underwent it I year after pelvic reconstructive surgery using polypropylene mesh. Foreign body response to the mesh was assessed using a combination of histological, semiquantitative and computerized image based analysis. Results: Compared to preoperative histology there was a significant postoperative increase in macrophage and mast cell counts (p = 0.03 and 0.01) but no significant changes in the count of cells involved primarily in the infectious cell response or collagen density and the elastin area fraction at the mesh-tissue interface (p = 0.2 and 0.3, respectively). Three cases of mild granuloma formation and 2 of mild erosion were observed. There was no significant change in epithelial thickness when comparing preoperative and postoperative samples. Conclusions: When used for pelvic reconstructive surgery, macroporous monofilament polypropylene mesh induces a mild but persistent foreign body reaction.

Place, publisher, year, edition, pages
2009. Vol. 181, no 3, 1189-1195 p.
Keyword [en]
urethra, prolapse, foreign-body reaction, suburethral slings, polypropylenes
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-130023DOI: 10.1016/j.juro.2008.11.030ISI: 000263321800102OAI: oai:DiVA.org:uu-130023DiVA: diva2:345879
Available from: 2010-08-27 Created: 2010-08-27 Last updated: 2010-08-27Bibliographically approved

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