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Tissue distribution of (35)S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure
Karolinska Institutet.
Stockholms Universitet.
Stockholms Universitet.
Stockholms Universitet.
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2010 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 30, no 4, 558-565 p.Article in journal (Refereed) Published
Abstract [en]

Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival. Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to (35)S-PFOS (12.5mg/kg), we determined the distribution in dams, fetuses (GD18 and GD20) and pups (postnatal day 1, PND1) employing whole-body autoradiography and liquid scintillation counting. In dams, levels were highest in liver and lungs. After placental transfer, (35)S-PFOS was present on GD18 at 2-3 times higher levels in lungs, liver and kidneys than in maternal blood. In PND1 pups, levels in lungs were significantly higher than in GD18 fetuses. A heterogeneous distribution of (35)S-PFOS was observed in brains of fetuses and pups, with levels higher than in maternal brain. This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages.

Place, publisher, year, edition, pages
2010. Vol. 30, no 4, 558-565 p.
Keyword [en]
Perfluorooctane sulfonate (PFOS), Perfluoroalkylated compounds (PFCs), Autoradiography, Liquid scintillation counting, Perinatal, Tissue distribution, C57Bl/6 mouse
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-130040DOI: 10.1016/j.reprotox.2010.07.004ISI: 000285036300007PubMedID: 20656018OAI: oai:DiVA.org:uu-130040DiVA: diva2:345981
Available from: 2010-08-30 Created: 2010-08-30 Last updated: 2017-12-12

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Halldin, KristerBergström, Ulrika

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