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Enhanced neurokinin 1 receptor availability in the amygdala in posttraumatic stress disorder
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
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(English)Manuscript (preprint) (Other academic)
Abstract [en]

Background: Posttraumatic stress disorder (PTSD) may result from experiencing severe distress, and is in part amygdala dependent. Animal studies demonstrate that stress and negative affect enhance the amygdala-release of the neuropeptide substance P (SP) which binds to the neurokinin 1 (NK1) receptor. This positron emission tomography (PET) study investigated if NK1 receptor availability in the amygdala of PTSD patients were different from healthy control subjects. Methods: Eleven male patients with DSM-IV defined PTSD and nine healthy male control subjects were PET scanned during 60 min at rest using the NK1 preferring tracer [11C]GR205171. Parametric Patlak images were generated and analyzed using statistical parametric mapping software. The effect of age was co-varied out because the amount of NK1 receptors decline with age. Results: PTSD patients had elevated uptake of [11C]GR205171 in the amygdala as compared to controls, also when anxiety differences were controlled for. Conclusions: We suggest that enhanced NK1 receptor availability could be a risk factor for developing PTSD rather than reflecting trauma induced alterations.

Keyword [en]
PTSD; NK1 receptor; substance P; PET; amygdala; STAI-S
National Category
Psychiatry
Research subject
Neuroscience
Identifiers
URN: urn:nbn:se:uu:diva-130093OAI: oai:DiVA.org:uu-130093DiVA: diva2:346314
Available from: 2010-08-31 Created: 2010-08-31 Last updated: 2011-02-25Bibliographically approved

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Michelgård Palmquist, Åsa

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Psychiatry, University HospitalDepartment of Oncology, Radiology and Clinical ImmunologyDepartment of Psychology
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