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Targeted radionuclide therapy in head and neck cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
2010 (English)In: Head and Neck, ISSN 1043-3074, E-ISSN 1097-0347, Vol. 32, no 5, 666-678 p.Article, review/survey (Refereed) Published
Abstract [en]

There is great potential for targeted radionuclide therapy (TRT) in the treatment of head and neck cancer. In recent years, developments in fields such as antigen screening, protein engineering, and cancer biology have facilitated the rational design of targeted pharmaceuticals, with monoclonal antibodies forming the most rapidly expanding category. TRT may be a promising way to improve targeted treatment, especially in head and neck cancer, because of the intrinsic radiosensitivity of this tumor type. TRT may also provide a good foundation on which to build rational biologic combination therapies. In the next few years the use of TRT may offer new opportunities for further improvement of the therapeutic ratio that potentially may obviate or reduce the need for conventional cytotoxics.

Place, publisher, year, edition, pages
2010. Vol. 32, no 5, 666-678 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-130149DOI: 10.1002/hed.21243ISI: 000277347100016PubMedID: 19827126OAI: oai:DiVA.org:uu-130149DiVA: diva2:346752
Available from: 2010-09-02 Created: 2010-09-02 Last updated: 2017-12-12Bibliographically approved

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