uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Should blood flow during cardiopulmonary bypass be individualized more than to body surface area?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Show others and affiliations
2011 (English)In: Perfusion, ISSN 0267-6591, E-ISSN 1477-111X, Vol. 26, no 1, 45-50 p.Article in journal (Refereed) Published
Abstract [en]

Blood flow during cardiopulmonary bypass (CPB) is calculated on body surface area (BSA). Increasing comorbidity, age and weight of today's cardiac patients question this calculation as it may not reflect individual metabolic requirement. The hypothesis was that a measured cardiac index (CI) prior to normothermic CPB is a better estimate. A cross-over study, with random allocation to CPB blood flow for 20 minutes based on either a calculation (2.4 L/min/m(2)) or on CI, with a switch to the opposite flow for another 20 minutes, was performed. Twenty-two elective cardiac surgery patients with normal ventricular function were included. Effect parameters were cerebral oxygenation, mixed venous saturation and arterial lactate. CI varied from 1.9 to 3.1 L/min/m(2) (median 2.4 L/min/m(2)). No differences in effect parameters were seen. In conclusion, a CPB blood flow based on an individual estimate did not improve cerebral and systemic oxygenation compared to a blood flow based on BSA.

Place, publisher, year, edition, pages
2011. Vol. 26, no 1, 45-50 p.
Keyword [en]
blood flow, body surface area, cardiac index, cardiac output, cardiopulmonary bypass, near-infrared spectroscopy
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-130526DOI: 10.1177/0267659110382062ISI: 000285541900006PubMedID: 20736244OAI: oai:DiVA.org:uu-130526DiVA: diva2:349867
Available from: 2010-09-09 Created: 2010-09-09 Last updated: 2011-01-31Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Anaesthesiology and Intensive Care
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 188 hits
ReferencesLink to record
Permanent link

Direct link