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Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences. (BMS)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences. (BMS)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences.
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2010 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 584, no 12, 2670-2680 p.Article, review/survey (Refereed) Published
Abstract [en]

Affibody molecules are a class of engineered affinity proteins with proven potential for therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 kDa) single domain proteins that can be isolated for high affinity and specificity to any given protein target. Fifteen years after its discovery, the Affibody technology is gaining use in many groups as a tool for creating molecular specificity wherever a small, engineering compatible tool is warranted. Here we summarize recent results using this technology, propose an Affibody nomenclature and give an overview of different HER2-specific Affibody molecules. Cumulative evidence suggests that the three helical scaffold domain used as basis for these molecules is highly suited to create a molecular affinity handle for vastly different applications.

Place, publisher, year, edition, pages
2010. Vol. 584, no 12, 2670-2680 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-130774DOI: 10.1016/j.febslet.2010.04.014ISI: 000278031800022PubMedID: 20388508OAI: oai:DiVA.org:uu-130774DiVA: diva2:351085
Available from: 2010-09-13 Created: 2010-09-13 Last updated: 2017-12-12Bibliographically approved

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Feldwisch, JoachimTolmachev, VladimirCarlsson, JörgenFrejd, Fredrik Y.

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