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Determination of the relative glomerular filtration rate of each kidney in man: Comparison between iohexol CT and 99mTc-DTPA scintigraphy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
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1995 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 36, no 4, 410-417 p.Article in journal (Refereed) Published
Abstract [en]

Iohexol and 99mTc-DTPA were used in 43 patients to determine the relative glomerular filtration rate (GFR), i.e., the GFR of each kidney in percent of total GFR. The amount of any GFR marker accumulating in Bowman's space, tubuli and renal pelvis within a few minutes after i.v. injection, before any marker had left the kidney via the ureter, was defined as proportional to the GFR of that kidney. The renal accumulation of iohexol was determined by CT using 10 slices of 8-mm thickness 1 to 4 minutes after injection. The renal accumulation of 99mTc-DTPA was determined with a gamma camera within 2 minutes after injection. The correlation coefficient between the two methods was 0.98. Due to the higher radiation dose from CT than from 99mTc-DTPA injection, relative GFR determination with CT should be performed when there is also a diagnostic need to reveal morphology.

Place, publisher, year, edition, pages
1995. Vol. 36, no 4, 410-417 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-130809PubMedID: 7619622OAI: oai:DiVA.org:uu-130809DiVA: diva2:351282
Available from: 2010-09-13 Created: 2010-09-13 Last updated: 2017-12-12Bibliographically approved

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