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Præoperativ funktionel magnetisk resonans-billeddannelse hos patienter med hjernetumor
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2010 (Danish)In: Ugeskrift for læger, ISSN 0041-5782, E-ISSN 1603-6824, Vol. 172, no 35, 2370-2376 p.Article in journal (Refereed) Published
Abstract [da]

INTRODUCTION: Functional Magnetic Resonance Imaging (fMRI) allows important functions in the brain cortex to be mapped noninvasively. The purpose with this work was to investigate a possible correlation between the distance from the tumour margin to fMRI activity and postoperative neurological deficits by means of a standardised method for measurement of distance. A second purpose was to investigate the influence of preoperative fMRI on the neurosurgical decision-making process. MATERIAL AND METHODS: Retrospective study of 25 patients. The inclusion criteria were surgery or biopsy after fMRI plus a three-month postoperative assessment. A total of 14 patients complied with these requirements (six men and eight women, the mean age was 39 years). fMRI raw data was collected using a three tesla magnetic resonance scanner (Signa HDx R14M5, GE Healthcare). The distance from the tumour margin to fMRI activation was measured using GE-reformat version 4.2 after raw data had been postprocessed using GE BrainwavePA version 1.3.08130. The neurosurgeons valuation of fMRI in the preoperative decision-making process was obtained using a standard questionnaire. RESULTS: There was a trend of association between distance from tumour to eloquent functional areas and the patients' postoperative neurological outcome (Fisher's exact test: distance < 15 mm, p = 0.43; distance < 10 mm, p = 0.14). fMRI proved very useful when deciding whether to operate or not (42%), when deciding the surgical approach (50%) and when deciding the extent of the surgical approach (83%). CONCLUSION: The standardised method for measurement of distance between tumour margin and fMRI activity can contribute to the preoperative risk assessment in patients with brain tumours.

Place, publisher, year, edition, pages
2010. Vol. 172, no 35, 2370-2376 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-130852PubMedID: 20825741OAI: oai:DiVA.org:uu-130852DiVA: diva2:351514
Note
Title in english: Preoperative functional magnetic resonance imaging in patients with brain tumorsAvailable from: 2010-09-14 Created: 2010-09-14 Last updated: 2017-12-12Bibliographically approved

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Larsson, Elna-Marie

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