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Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
2011 (English)In: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 32, no 6, 984-992 p.Article in journal (Refereed) Published
Abstract [en]

SUMMARY: CNS lymphoma consists of 2 major subtypes: secondary CNS involvement by systemic lymphoma and PCNSL. Contrast-enhanced MR imaging is the method of choice for detecting CNS lymphoma. In leptomeningeal CNS lymphoma, representing two-thirds of secondary CNS lymphomas, imaging typically shows leptomeningeal, subependymal, dural, or cranial nerve enhancement. Single or multiple periventricular and/or superficial contrast-enhancing lesions are characteristic of parenchymal CNS lymphoma, representing one-third of secondary CNS lymphomas and almost 100% of PCNSLs. New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions. Advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis. Furthermore, these imaging techniques may play a pivotal role in planning targeted therapies, prognostication, and monitoring treatment response.

Place, publisher, year, edition, pages
2011. Vol. 32, no 6, 984-992 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-131172DOI: 10.3174/ajnr.A2171PubMedID: 20616176OAI: oai:DiVA.org:uu-131172DiVA: diva2:353405
Available from: 2010-09-27 Created: 2010-09-27 Last updated: 2012-03-12Bibliographically approved

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