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Gastrointestinal neuroendocrine tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kjell Öberg)
2010 (English)In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 21, no Suppl 7, vii72-vii80 p.Article in journal (Refereed) Published
Abstract [en]

Gastrointestinal neuroendocrine tumors (GI-NETs) are a genetically diverse group of malignancies that sometimes produce peptides causing characteristic hormonal syndromes. NETs can be clinically symptomatic (functioning) or silent (non-functioning); both types frequently synthesize more than one peptide, although often these are not associated with specific syndromes. Based on data from various sources the incidence and prevalence of GI-NETs is increasing. Surgery is the only possible curative approach and so represents the traditional first-line therapy. However, as most patients with NETs are diagnosed once metastases have occurred, curative surgery is generally not possible. Patients therefore require medical management with the aim of relieving symptoms and suppressing tumor growth and spread. Somatostatin analogues can improve the symptoms of carcinoid syndrome and stabilize tumor growth (PROMID study) in many patients. An antiproliferative effect can also be achieved with the m-TOR inhibitor everolimus, alone or in combination with octreotide LAR. The vascular endothelial growth factor inhibitor sunitinib has demonstrated antitumor effects in pancreatic NETs. Pasireotide, the multi-receptor targeted somatostatin analogue, has the potential to be an effective therapy for de novo or octreotide-refractory carcinoid syndrome. Peptide receptor radiotherapy with yttrium 90-DOTATOC or lutetium 177-DOTATE are also new interesting treatment options for NETs.

Place, publisher, year, edition, pages
Oxford University Press , 2010. Vol. 21, no Suppl 7, vii72-vii80 p.
Keyword [en]
chemotherapy, neuroendocrine tumors, PRRT, somatostatin analogues, surgery, VEGF inhibitors
National Category
Cancer and Oncology
URN: urn:nbn:se:uu:diva-132017DOI: 10.1093/annonc/mdq290ISI: 000283099200009OAI: oai:DiVA.org:uu-132017DiVA: diva2:356585
Available from: 2010-10-13 Created: 2010-10-13 Last updated: 2010-11-19Bibliographically approved

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