Cellens kalciumjonsignalering: från grundforskning till patientnytta
2005 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 102, no 44, 3214-3219 p.Article in journal (Refereed) Published
A large number of ion channels, enzymes, pumps and binding proteins participate in the generation of intracellular Ca2+ signals and their decoding. Ca2+ signalling takes place in the form of oscillations, waves and sparks. Such Ca2+ signals occur in almost all cells and regulate diverse cell functions. Perturbation of Ca2+ signalling leads to disease states. Drugs that act on Ca2+-signalling are commonly used in treatment of several diseases. Different molecules involved in Ca2+ signalling are potential targets for development of new therapies. Thus, basic research in Ca2+ signalling increases our understanding of the pathogenesis of diseases at a molecular level and the likelihood of development of new therapeutic modalities.
Place, publisher, year, edition, pages
2005. Vol. 102, no 44, 3214-3219 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-132139PubMedID: 16329451OAI: oai:DiVA.org:uu-132139DiVA: diva2:357053