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Ca(2+)-induced Ca2+ release in insulin-secreting cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
1992 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 296, no 3, 287-291 p.Article in journal (Refereed) Published
Abstract [en]

The sulphydryl reagent thimerosal (50 microM) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells. This release was reversed after addition of the reducing agent dithiothreitol. Ca2+ was released from an Ins(1,4,5)P3-insensitive pool, since release was observed even after depletion of the Ins(1,4,5)P3-sensitive pool by a supramaximal dose of Ins(2,4,5)P3 or thapsigargin. The Ins(1,4,5)P3-sensitive pool remained essentially unaltered by thimerosal. Thimerosal-induced Ca2+ release was potentiated by caffeine. These findings suggest the existence of Ca(2+)-induced Ca2+ release also in insulin-secreting cells.

Place, publisher, year, edition, pages
1992. Vol. 296, no 3, 287-291 p.
Keyword [en]
Ca2+-induced Ca2+ release, Sulphydryl reagent, Thimerosal, Intracellular Ca2+ transport, Insulin-secreting cell, Permeabilized cell
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-132306DOI: 10.1016/0014-5793(92)80306-2PubMedID: 1537406OAI: oai:DiVA.org:uu-132306DiVA: diva2:357429
Available from: 2010-10-18 Created: 2010-10-18 Last updated: 2010-10-26Bibliographically approved

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