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Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
1997 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 238, no 3, 851-855 p.Article in journal (Refereed) Published
Abstract [en]

In addition to its interaction at hypothalamic sites to affect feeding and energy expenditure, leptin has been shown to exhibit a proliferative response in erythropoietic cells. The functional leptin receptor is also present in pancreatic islets and we now demonstrate that a commonly used clonal insulin secreting beta-cell line, RINm5F, expresses high levels of the Ob-Rb mRNA. Leptin causes an increase in tyrosine phosphorylation of a number of intracellular proteins and a dose related (10 nM-200 nM) increase in expression of the immediate-early gene, c-fos. This precedes a leptin induced proliferative response in serum-deprived RINm5F cells, which suggests that leptin might be involved in the complex regulation of proliferation of the pancreatic beta-cell.

Place, publisher, year, edition, pages
1997. Vol. 238, no 3, 851-855 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-132293DOI: 10.1006/bbrc.1997.7399PubMedID: 9325180OAI: oai:DiVA.org:uu-132293DiVA: diva2:357446
Available from: 2010-10-18 Created: 2010-10-18 Last updated: 2010-10-28Bibliographically approved

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