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Cell signaling by the type IV pili of pathogenic Neisseria
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
1998 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 273, no 34, 21777-21782 p.Article in journal (Refereed) Published
Abstract [en]

Neisseria gonorrhoeae and Neisseria meningitidis are Gram-negative bacterial pathogens that infect human mucosal epithelia. Type IV pilus-mediated adherence of these bacteria is a crucial early event for establishment of infection. In this work, we show that the type IV pili transduce a signal into the eucaryotic host cell. Purified adherent pili, but not pili from a low binding mutant, trigger an increase in the cytosolic free calcium ([Ca2+]i) in target epithelial cells, a signal known to control many cellular responses. The [Ca2+]i increase was blocked by antibodies against CD46, a putative pilus receptor, suggesting a role for this protein in signal transduction. Pilus-mediated attachment was inhibited by depletion of host cell intracellular Ca2+ stores but not by removal of extracellular Ca2+. Further, kinase inhibition studies showed that pilus-mediated adherence is dependent on casein kinase II. In summary, these data reveal a novel function of the type IV pili, namely induction of signal transduction pathways in host cells.

Place, publisher, year, edition, pages
1998. Vol. 273, no 34, 21777-21782 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-132288DOI: 10.1074/jbc.273.34.21777PubMedID: 9705315OAI: oai:DiVA.org:uu-132288DiVA: diva2:357450
Available from: 2010-10-18 Created: 2010-10-18 Last updated: 2017-12-12Bibliographically approved

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