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Coexistence of passive and carrier-mediated processes in drug transport
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2010 (English)In: Nature reviews. Drug discovery, ISSN 1474-1776, Vol. 9, no 8, 597-614 p.Article in journal (Refereed) Published
Abstract [en]

The permeability of biological membranes is one of the most important determinants of the pharmacokinetic processes of a drug. Although it is often accepted that many drug substances are transported across biological membranes by passive transcellular diffusion, a recent hypothesis speculated that carrier-mediated mechanisms might account for the majority of membrane drug transport processes in biological systems. Based on evidence of the physicochemical characteristics and of in vitro and in vivo findings for marketed drugs, as well as results from real-life discovery and development projects, we present the view that both passive transcellular processes and carrier-mediated processes coexist and contribute to drug transport activities across biological membranes.

Place, publisher, year, edition, pages
2010. Vol. 9, no 8, 597-614 p.
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Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-132385DOI: 10.1038/nrd3187ISI: 000280496900022PubMedID: 20671764OAI: oai:DiVA.org:uu-132385DiVA: diva2:357721
Available from: 2010-10-19 Created: 2010-10-19 Last updated: 2010-12-07Bibliographically approved

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